Methyl Salicylate
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Methyl Salicylate

Methyl salicylate 's cas code is 119-36-8.

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Product Description

Methyl salicylate Basic information

description application Uses Production Method

Product Name:

Methyl salicylate









Mol File:


Methyl salicylate Chemical Properties

Melting point 

-8 °C

Boiling point 

222 °C(lit.)


1.174 g/mL at 25 °C(lit.)

vapor density 

5.26 (vs air)

vapor pressure 

1 mm Hg ( 54 °C)

refractive index 

n20/D 1.536(lit.)




226 °F


Very slightly soluble in water, miscible with ethanol (96 per cent) and with fatty and essential oils.




pKa 9.90 (Uncertain)


Clear colorless to pale yellow

Water Solubility 

0.07 g/100 mL (20 ºC)

JECFA Number







Stable. Incompatible with strong oxidizing agents, strong bases.



CAS DataBase Reference

119-36-8(CAS DataBase Reference)

NIST Chemistry Reference

2-Hydroxybenzoic acid methyl ester(119-36-8)

EPA Substance Registry System

Methyl salicylate (119-36-8)

Methyl salicylate Safety Information

Hazard Codes 


Risk Statements 


Safety Statements 




WGK Germany 





Autoignition Temperature

847 °F







HS Code 


Hazardous Substances Data

119-36-8(Hazardous Substances Data)


LD50 orally in rats: 887 mg/kg (Jenner)

Methyl salicylate Usage And Synthesis


Natural material is found in wintergreen oil, oil of wintergreen, birch oil, green tea seed oil, clove oil, Quercetin tree oil, tuberose oil, small when medicated oil, tea oil, ylang ylang oil and cherry, apple, strawberry fruit juice. It is colorless or pale yellow, red or light yellow transparent oily liquid. A strong aroma of wintergreen oil. Relative molecular mass of 152.16. The relative density of 1.1738. Melting point-8.6 ℃. Boiling point 223.3 ℃. A flash point of 96 ℃. The refractive index of 1.5360. It is insoluble in water, soluble in alcohol, ether, acetic acid and other common organic solvents. It is easy to change when exposed in air . Rat oral LD50887mg/kg. 
Salicylic acid and methanol are heated to prepare it in the presence of sulfuric acid . Or it is made of stone STSP plant holly leaf through distillation. 
Methyl salicylate can be used in the formulation of flavors, mainly for the deployment of ylang ylang, tuberose, chypre, acacia, fougere, orchids. But the most common use is perfuming toothpaste. IFRA has no restrictions. Methyl salicylate is recognized as GRAS by FEMA, FEMA number 2745, the European Council includes methyl salicylate in health artificial flavorants table which can be used in food without harm to human , the maximum amount is 8400mg/kg, ADI value is 0.5mg/kg. 
Methyl salicylate can be used for food flavor formula, is a food flavor within China's GB2760-1996 provisions of the temporary use , ADI value of 0 to 0.5, is commonly used in the deployment of strawberry, vanilla, grapes and other fruit-flavor flavor for food and beer, but also flavor fructose, soft drinks.Methyl salicylate is also used as preservatives, pesticides, polishes, inks, paints, polyester dye carriers in industrial fields


Methyl salicylate ointment is a common dermatology drug with analgesic, anti-inflammatory, bactericidal effect. Because it can induce local irritation, it is rarely orally used.When spread in the skin,it is easily absorbed. Its liniments, ointments can be used for acute rheumatoid arthritis, low back pain and muscle pain, also itching and flavoring agents, flavoring agents, preservatives.

Production Method

Methyl salicylate is widespread in nature, and it is a main ingredient of wintergreen, small medicated oil . Alsoit is present in essential oils of the tuberose, Quercetin tree, ylang ylang, cloves, tea. Salicylic acid and methanol are used to make it in the presence of sulfuric acid through esterification. Salicylic acid is dissolved in methanol, add sulfuric acid, heat with stirring, the reaction time is 3h,90-100℃, cool to below 30 ℃,take oil ,wash with sodium carbonate solution to pH8 above, and then wash 1 time with water. Vacuum distillation, collect 95-110 ℃ (1.33-2.0kPa) distillate, obtain methyl salicylate. The yield is over 80%. General industrial methyl salicylate content is 99.5%. Material consumption fixed: Acid 950kg/t, methanol 400kg/t.


Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester that is naturally produced by many species of plants. Some of the plants which produce it are called wintergreens, hence the common name. This compound is used as a fragrance. It is also found in liniments (rubbing ointments).

Chemical Properties

Methyl salicylate has a characteristic wintergreen-like odor. May be prepared by extraction from natural sources; or by esterification of salicylic acid with methanol.

Chemical Properties

Methyl salicylate has a minty, spicy, sweet, wintergreen-like odor.

Chemical Properties

Wintergreen is an evergreen shrub with slender, creeping stems, assurgent, flowering branches with toothed leaves clustered at the top, white, bell-shaped flowers blossoming July to August, followed by red berries (checkerberries). The plant grows extensively in the woods of Canada and the United States (Pennsylvania). The leaves are harvested between June and September. Wintergreen has an aromatic odor and flavor similar to methyl salicylate.

Chemical Properties

colourless liquid with an odour of wintergreen

Chemical Properties

Methyl Salicylate is the main component of wintergreen oil and occurs in small quantities in other essential oils and fruits. It is a colorless liquid with a sweet, phenolic odor.


antipyretic analgesics


Methyl salicylate is an organic ester that is commonly produced naturally by wintergreens. Methyl salicylate is utilize as a anti-herbivore defense system in various plants that produces it. Methyl sa licylate is also used in high concentrations as a rubefacient to treat joint, muscular pain and acute pain. Methyl slicylate is also used as a flavoring agent and often used to provide fragrance to pr oducts.


Potent inhibitor of ornithine decarboxylase


In perfumery; for flavoring candies, etc.


Methyl salicylate occurs in the leaves ofGaultheria procumbens L. and in the barkof Betulaceae. It is produced by esterificationof salicylic acid with methanol. It is used inperfumery and as a flavoring agent.


Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized, but in the past, it was commonly distilled from the twigs of Betula lenta (sweet birch) and Gaultheria procumbens (eastern teaberry or winter green).


ChEBI: A benzoate ester that is the methyl ester of salicylic acid.


Toxic by ingestion; use in foods restrictedby FDA, lethal dose 30 cc in adults, 10 cc in chil-dren.

Health Hazard

Harmful if swallowed, inhaled, absorbed through skin. Vapor mist is irritating to the eyes, mucous membranes, upper respiratory tract and skin. Ingestion of relatively small amount causes severe poisoning and death. Causes nausea, vomiting, acidosis, pulmonary edema, pneumonia, convulsions and death.

Fire Hazard

Methyl salicylate is combustible.

Contact allergens

This anti-inflammatory agent is found in a wide number of ointments and can induce allergic contact dermatitis.

Chemical Synthesis

By esterification from natural sources; by esterification of salicylic acid with methanol


Available data suggest that methyl salicylate is not carcinogenic.

Methyl salicylate Preparation Products And Raw materials

Raw materials

Methanol-->Sulfuric acid-->Sodium carbonate-->Salicylic acid-->Clove oil-->Salicylic acid Industry Grade

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