Benzophenone
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Benzophenone

Benzophenone flakes's cas code is 119-61-9

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Product Description

Benzophenone Basic information


description Chemical Properties application Uses indicator Toxicity Production method


Product Name:

Benzophenone

Synonyms:

BENZOPHENONE, 99%BENZOPHENONE, 99%BENZOPHENONE, 99%BENZOPHENONE, 99%;erbnejiatong;Dimenhydrinate EP Impurity J(Benzophenone);Diphenhydramine Impurity 5(Diphenhydramine EP Impurity E);Dimenhydrinate EP Impurity J;photo sensitizer BP;Pipenzolate Impurity 2(Benzophenone);Benzophenone whatsapp+86 19930203281

CAS:

119-61-9

MF:

C13H10O

MW:

182.22

EINECS:

204-337-6

Mol File:

119-61-9.mol



Benzophenone Chemical Properties


Melting point 

47-51 °C(lit.)

Boiling point 

305 °C(lit.)

density 

1.11

vapor density 

4.21 (vs air)

vapor pressure 

1 mm Hg ( 108 °C)

FEMA 

2134 | BENZOPHENONE

refractive index 

1.5893

Fp 

>230 °F

storage temp. 

Refrigerator

solubility 

ethanol: soluble100mg/mL, clear, colorless (80% ethanol)

form 

Crystalline Powder or Flakes

color 

White to off-white

Odor

Characteristic.

Water Solubility 

insoluble (<0.1 g/100 mL at 25 ºC)

JECFA Number

831

Merck 

14,1098

BRN 

1238185

Stability:

Stable. Incompatible with strong oxidizing agents, strong reducing agents. Combustible.

InChIKey

RWCCWEUUXYIKHB-UHFFFAOYSA-N

CAS DataBase Reference

119-61-9(CAS DataBase Reference)

NIST Chemistry Reference

Benzophenone(119-61-9)

EPA Substance Registry System

Benzophenone (119-61-9)


Benzophenone Safety Information


Hazard Codes 

Xi,N,Xn,F

Risk Statements 

36/37/38-52/53-50/53-67-65-62-51/53-48/20-11-40

Safety Statements 

26-61-37/39-29-60-36-62-36/37-33-16-9

RIDADR 

UN 3077 9/PG 3

WGK Germany 

2

RTECS 

DI9950000

10

TSCA 

Yes

HazardClass 

9

PackingGroup 

III

HS Code 

29143900

Hazardous Substances Data

119-61-9(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit 3535 mg/kg


Benzophenone Usage And Synthesis


Toxicity

GRAS(FEMA)。
LD502897mg/kg(Mice, orally)。

Production method

There are different methods. 1. Condensation of benzyl chloride and benzene , and then by nitric acid oxidation. 2. The condensation of benzene and carbon tetrachloride, and then by hydrolysis. In the laboratory, the production is based on aluminum chloride as a catalyst, prepared by reacting benzene with benzoyl chloride.3.Condensation of benzene and benzoyl chloride in the presence of aluminum chloride, and then crystallized from ethanol.

Chemical Properties

Orange Crystals

Chemical Properties

Benzophenone is a combustible, white, crystalline solid with a rose-like odor

Uses

It is used in the manufacturing of antihistamines, hypnotics, insecticides.

Uses

Reported to bind monsaccharides in the presence of polysaccharides

Uses

Benzophenone is used as a synthetic intermediate for manufacture of pharmaceuticals and agricultural chemicals. It is also used as a photoinitiator in UV-curable printing inks, as a fragrance in perfumes, as a flavor enhancer in foods. Benzophenone can be added as a UV-absorbing agent to plastics, lacquers, and coatings at concentrations of 2–8%.

Production Methods

Benzophenone is commercially synthesized by the atmospheric oxidation of diphenylmethane using a catalyst of copper naphthenate. Alternatively, it can be produced by a Friedel–Crafts acylation of benzene using either benzoyl chloride or phosgene in the presence of aluminum chloride .

Preparation

By Friedel–Craft condensation of benzene with benzoyl chloride in the presence of aluminum chloride.

Carcinogenicity

Lifetime dermal carcinogenicity studies in mice and rabbits did not show any tumor excess in the treated animals. Female Swiss mice and New Zealand White rabbits of both sexes were treated dermally with 0, 5, 25, or 50% of benzophenone (0.02 mL) twice a week for 120 or 180 weeks. Weekly examination of the rabbits did not reveal any reduction in survival or appearance of tumors. Mice treated with benzophenone did not show any excess in the number of tumor-bearing animals or in total number of tumors compared to untreated control animals. Although three skin tumors were observed in the benzophenone- treated mice (one case of squamous cell carcinoma and two cases of squamous cell papilloma), there were also three tumors (one carcinoma and toe papillomas) observed in the control animals.


Benzophenone Preparation Products And Raw materials


Raw materials

Benzene-->Aluminium chloride-->Carbon tetrachloride-->Benzoyl chloride-->PHOSGENE-->Aluminium chloride hexahydrate


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