Natural Butyric Acid

Product Name:

Natural butyric acid

CAS:

107-92-6

MF:

C4H8O2

MW:

88.11

EINECS:

203-532-3

Mol File:

107-92-6.mol

Melting point 

−6-−3 °C(lit.)

Boiling point 

162 °C(lit.)

density 

0.964 g/mL at 25 °C(lit.)

vapor density 

3.04 (vs air)

vapor pressure 

0.43 mm Hg ( 20 °C)

refractive index 

n20/D 1.398(lit.)

FEMA 

2221 | BUTYRIC ACID

Fp 

170 °F

storage temp. 

-20°C

pka

4.83(at 25℃)

form 

Liquid

color 

Clear colorless

Specific Gravity

0.960 (20/4℃)

PH

2.5 (100g/l, H2O, 20℃)

Odor Threshold

0.00019ppm

explosive limit

2-12.3%(V)

Water Solubility 

MISCIBLE

JECFA Number

87

Merck 

14,1593

BRN 

906770

Stability:

Stability Flammable. Incompatible with strong oxidizing agents, aluminium and most other common metals, alkalies, reducing agents.

InChIKey

FERIUCNNQQJTOY-UHFFFAOYSA-N

CAS DataBase Reference

107-92-6(CAS DataBase Reference)

NIST Chemistry Reference

Butanoic acid(107-92-6)

EPA Substance Registry System

Butyric acid (107-92-6)

Hazard Codes 

C,Xi

Risk Statements 

34

Safety Statements 

26-36-45

RIDADR 

UN 2820 8/PG 3

WGK Germany 

1

RTECS 

ES5425000

F 

13

Autoignition Temperature

824 °F

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

2915 60 19

HazardClass 

8

PackingGroup 

III

Hazardous Substances Data

107-92-6(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 8.79 g/kg (Smyth)

ALFA

English

Chemical Properties

n-Butyric acid has a persistent, penetrating, rancid, butter-like odor and burning, acid taste.

Uses

It is used in plastics as a raw material for the cellulose acetate butyrate (CAB). Other uses of butyric acid are in disinfectants, pharmaceuticals, and feed supplements for plant and animals. Butyric acid derivatives play an important role in plant and animal physiology.

Definition

ChEBI: A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.

Production Methods

Butyric acid is produced by oxidation of butyraldehyde (CH3(CH2)2CHO) or butanol (C4H9OH). It can also be formed biologically by the oxidation of sugar and starches using bacteria.

Definition

A colorless liquid carboxylic acid. Esters of butanoic acid are present in butter.

Aroma threshold values

Detection: 240 ppb to 4.8 ppm

Taste threshold values

Taste characteristics at 250 ppm: acidic, sour, cheesy, dairy, creamy with a fruity nuance.

General Description

A colorless liquid with a penetrating and unpleasant odor. Flash point 170°F. Corrosive to metals and tissue. Density 8.0 lb /gal.

Air & Water Reactions

Water soluble.

Reactivity Profile

(3R,4S)-1-Benzoyl-3-(1-methoxy-1-methylethoxy)-4-phenyl-2-azetidinone can react with oxidizing agents. Incandescent reactions occur with chromium trioxide above 212°F. Also incompatible with bases and reducing agents. May attack aluminum and other light metals .

Hazard

Strong irritant to skin and tissue.

Health Hazard

Inhalation causes irritation of mucous membrane and respiratory tract; may cause nausea and vomiting. Ingestion causes irritation of mouth and stomach. Contact with eyes may cause serious injury. Contact with skin may cause burns; chemical is readily absorbed through the skin and may cause damage by this route.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Biotechnological Applications

Butyrate is produced as end - product of a fermentation process solely performed by obligate anaerobic bacteria. Fermented Kombucha "tea" includes butyric acid as a result of the fermentation. This fermentation pathway was discovered by Louis Pasteur in 1861.
The pathway starts with the glycolytic cleavage of glucose to two molecules of pyruvate, as happens in most organisms. Pyruvate is then oxidized into acetyl coenzyme A using a unique mechanism that involves an enzyme system called pyruvate - ferredoxin oxidoreductase. Two molecules of carbon dioxide (CO2) and two molecules of elemental hydrogen (H2) are formed as waste products from the cell.

Safety Profile

Moderately toxic by ingestion, skin contact, subcutaneous, intraperitoneal, and intravenous routes. Human mutation data reported. Severe skin and eye irritant. A corrosive material. Combustible liquid. Could react with oxidizing materials. Incandescent reaction with chromium trioxide above 100'. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

The United States Environmental Protection Agency rates and regulates butyric acid as a toxic substance.
Personal protective equipment such as rubber or PVC gloves, protective eye goggles, and chemical-resistant clothing and shoes are used to minimize risks when handling butyric acid.
Inhalation of butyric acid may result in soreness of throat, coughing, a burning sensation and laboured breathing. Ingestion of the acid may result in abdominal pain, shock, and collapse. Physical exposure to the acid may result in pain, blistering and skin burns, while exposure to the eyes may result in pain, severe deep burns and loss of vision.

Potential Exposure

In manufacture of butyrate esters, some of which go into artificial flavoring. Incompatibilities: May form explosive mixture with air. Incompatible with sulfuric acid, caustics, ammonia, aliphatic amines; isocyanates, strong oxidizers; alkylene oxides; epichlorohydrin

Shipping

UN2820 Butyric acid, Hazard class: 8; Labels: 8—Corrosive material. UN2529 Isobutyric acid, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material

Purification Methods

Distil the acid, them mix it with KMnO4 (20g/L), and fractionally redistil, discarding the first third of the distillate [Vogel J Chem Soc 1814 1948]. [Beilstein 2 IV 779.]

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.